Selecting the best ergonomic computer mouse to use is somewhat subjective which is why we carry a vast selection of ergonomic mice. Most people find using a computer mouse that minimizes the twisting of the wrist to be helpful. A vertical mouse such as the Evoluent Vertical Mouse or 3M Ergonomic Mouse will eliminate twisting. A number of research studies have supported use of the Handshoe Mouse, Orthomouse, and Smartfish Mouse as these mice provide for a healthy wrist angle, and encourage button clicking with the whole finger, instead of fingertips. Some uses will benefit from a non-traditional mouse such as the Central Pointing Device, or Foot Mouse.